Methods and apparatus for synthetic computed tomography image generation

A non-transitory computer readable medium storing instructions that, when executed by at least one processor, cause the at least one processor to perform operations comprising:

• receiving measurement data for a patient from an image scanning system;
• applying a first image-to-image network process to the measurement data to generate a plurality of initial synthetic images for a plurality of values of an imaging parameter;
• determining a region-of-interest (ROI) of the plurality of initial synthetic images based on patient data characterizing at least one object;
• generating an anatomical mask corresponding to each of the plurality of initial synthetic images based on the ROI;
• applying a second image-to-image network process to the patient data, at least a portion of the plurality of initial synthetic images that includes the ROI, and the anatomical masks to generate a plurality of final synthetic images for the plurality of values of an imaging parameter;
• and
• storing the plurality of final synthetic images in a data repository.

A system comprising:

• a database;
• and
• at least one processor communicatively coupled to the database and configured to:
• receive measurement data for a patient from an image scanning system;
• apply a first image-to-image network process to the measurement data to generate a plurality of initial synthetic images for a plurality of values of an imaging parameter;
• determine a region-of-interest (ROI) of the plurality of initial synthetic images based on patient data characterizing at least one object;
• generate an anatomical mask corresponding to each of the plurality of initial synthetic images based on the ROI;
• apply a second image-to-image network process to the patient data, at least a portion of the plurality of initial synthetic images that includes the ROI, and the anatomical masks to generate a plurality of final synthetic images for the plurality of values of an imaging parameter;
• and
• store the plurality of final synthetic images in a data repository.