Method for Stabilizing Hemoglobin and Reagents for Performing the Same
OwnerKeith D. Fourrier, Jacquelyn T. Hennek +5inventors
InventorsKeith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
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Abstract
A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.
Claims21
-21. (canceled)
A stool resuspension solution comprising one or more hemoglobin stabilization reagents selected from:
- protoporphyrin complexed with Zn2+;
- calcium ion or magnesium ion;
- a sugar or polysaccharide and, optionally, a polyvalent cation;
- an osmolyte;
- and
- a horseradish peroxidase (HRP) stabilization component and, optionally, a polyvalent cation.
Dependencies are inferred from the claim text.