US 2024/0402164 A1 · PLASMONIC CAGED NANOPLATFORMS AND METHODS THEREOF

Abstract

Methods are provided for making caged gold nanostars (C-GNSs). In one method, a layer of gold is deposited on the silver layer of bimetallic nanostar (BNS) particles in a galvanic replacement-free reaction and the silver is subsequently removed via hydrogen peroxide etching. In another method, gold ions are exchanged with the silver atoms of the BNS particles in a galvanic replacement reaction. Both methods result in a hollow gold shell around a gold nanostar core that enables loading with dyes for in vitro and in vivo detection of the C-GNSs and provides an internal standard in sensing. The C-GNS particles have a greater local electric field enhancement from the visible to the NIR spectral range relative to plasmonic-active GNSs of similar diameter that lack the hollow gold shell. Dye-loaded C-GNS particles are demonstrated for in vivo hyperspectral imaging and as photothermal transducers in the treatment of solid tumors.

Claims23

Dependent claims

A plasmonic-active caged gold nanostar, comprising:

one or more plasmonic-active caged gold nanostar particles having a hollow gold shell surrounding an essentially spherical core and a plurality of gold branches protruding out from the core, wherein a thickness of the gold shell is essentially uniform and tunable, and wherein the one or more plasmonic-active caged gold nanostar particles:
are essentially free of surfactant,
have a tunable plasmon resonance ranging from the visible to the near-infrared (NIR) spectral range, and
optionally, comprise one or more compounds encapsulated within the hollow gold shell.

1 more element

A method of making plasmonic-active caged gold nanostars, comprising:

dispersing one or more bimetallic nanostars into a basic polyvinylpyrrolidone solution, wherein the one or more bimetallic nanostars comprise a gold nanostar having a spherical core, a plurality of branches protruding out from the core, and a layer of silver on the core and extending outward onto the branches, wherein a tip of the branches are exposed gold;
and
performing one of the following two reactions:
i. exchanging gold ions with silver atoms of the bimetallic nanostar in a galvanic replacement reaction, or
ii. depositing gold ions to coat a silver surface of the bimetallic nanostars with a layer of gold in a galvanic replacement-free reaction, thereby forming one or more gold-coated bimetallic nanostars, and redispersing the one or more gold-coated bimetallic nanostars into a second solution of hydrogen peroxide to etch the gold layer and remove the silver,
thereby forming one or more plasmonic-active caged gold nanostars having a hollow gold shell surrounding the essentially spherical core.

3 more elements

Dependencies are inferred from the claim text.

Plasmonic caged nanoplatforms and methods thereof

Life of this patent

Plasmonic caged nanoplatforms and methods thereof

Life of this patent

Abstract

Claims23