Method of establishing cancer screening module, using method and platform thereof

A cancer screening platform, comprising:

• a low-resolution mass spectrometer configured to analyze a plurality of samples to obtain a plurality of mass spectral data, wherein the low-resolution mass spectrometer is a mass spectrometer with mass accuracy level above 5 ppm and a mass resolution below 10,000 m/Δm;
• and
• a cancer screening model comprising a computer processor and a memory, the memory storing a plurality of computer program instructions that, when executed by the computer processor, cause the computer processor to implement following steps, comprising:
• inputting the plurality of mass spectral data into a machine learning algorithm to obtain a plurality of markers by a feature selection method;
• and
• using the plurality of markers and a plurality of cancer statuses corresponding to the plurality of samples to establish the cancer screening model by the machine learning algorithm.

A cancer screening platform, comprising:

• a low-resolution mass spectrometer configured to analyze a specimen of a subject to obtain a subject mass spectral data, wherein the low-resolution mass spectrometer is a mass spectrometer with mass accuracy level above 5 ppm and a mass resolution below 10,000 m/Δm;
• and
• a cancer screening model comprising a computer processor and a memory, the memory storing a plurality of computer program instructions that, when executed by the computer processor, cause the computer processor to implement following steps, comprising:
• inputting at least one known marker;
• inputting the subject mass spectral data;
• and
• comparing the at least one known marker and the subject mass spectral data to evaluating a risk of a cancer for the subject.