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US 2024/0401112 A1Published application
Novel compounds and their applications
AssigneeSfc Co., Ltd.
InventorsDo Min LEE, Ho Young SI, Goutam MASANTA, Min Su EUM, Ju Man SONG, Bong Ki SHIN, Jong Tae JE
Life of this patent
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Abstract
The present invention relates to a novel compound and uses thereof, and more specifically, to a compound capable of labeling biomolecules (such as nucleic acids and proteins), a composition for labeling or detecting biomolecules containing the compound, a support for labeling or detecting biomolecules containing the compound, and a method of labeling or detecting biomolecules using the compound.
Claims24
A compound represented by Chemical Formula 1 below:
- Wherein,
- Ar1 and Ar2 are each independently a substituted or unsubstituted C6-C20 aryl or a substituted or unsubstituted C1-C20 heteroaryl containing at least one heteroatom,
- Y1 and Y2 are each independently CRaRb, NRc, O, or S,
- Q is O, S, or NRd,
- X1 to X6 are each independently CReRf,
- Ra to Rf and R1 to R3 are each independently
- (1) a functional group selected from hydrogen, deuterium, a substituted or unsubstituted C1-C40 alkyl, a substituted or unsubstituted C1-C40 heteroalkyl containing at least one heteroatom, a substituted or unsubstituted C2-C40 alkenyl, a substituted or unsubstituted C2-C40 alkynyl, a substituted or unsubstituted C3-C20 cycloalkyl, a substituted or unsubstituted C3-C20 cycloalkenyl, a substituted or unsubstituted C2-C20 heterocycloalkyl, hydroxy, oxido (—O−), a substituted or unsubstituted C1-C40 alkoxy, a substituted or unsubstituted C3-C40 cycloalkyloxy, a substituted or unsubstituted C5-C40 aryloxy, a substituted or unsubstituted C2-C40 heteroaryloxy, a substituted or unsubstituted C5-C50 aryl, a substituted or unsubstituted C2-C50 heteroaryl, a substituted or unsubstituted C5-C50 aralkyl, a substituted or unsubstituted C1-C40 alkylthio, a substituted or unsubstituted C5-C40 arylthio, a substituted or unsubstituted C3-C40 cycloalkylthio, a substituted or unsubstituted C2-C40 heteroarylthio, a substituted or unsubstituted acylamino, acyloxy, a substituted or unsubstituted phosphino, carboxylate (—CO2−), trifluoromethylsulfonyl (—SO2CF3), a substituted or unsubstituted ammonium, nitro, sulfonic acid (—SO3H), sulfonate, a substituted sulfonyl, a substituted sulfonic acid ester, a substituted or unsubstituted sulfonamide, a substituted thioketone, a trihalomethyl (—CF3, —CCl3, —CBr3, —CI3), a haloformyl (—COCl, —COBr, —COI), formyl (—CHO), acyl, carboxyl, a substituted ester, a substituted or unsubstituted aminocarbonyl, nitro, nitroso (—N═O), fluoro (—F), chloro (—Cl), bromo (—Br), iodo (—I), substituted or unsubstituted germanium, substituted or unsubstituted boron, substituted or unsubstituted aluminum, a substituted or unsubstituted silyl, a substituted or unsubstituted amide, carbamate, carboxylate, a substituted or unsubstituted phosphine, substituted or unsubstituted phosphoric acid, phosphate, phosphonic acid, phosphonate, nitrile, hydrazine, acetal, ketal, and polyalkylene oxide,
- (2) a functional group selected from carboxyl, a carboxyl derivative, hydroxyl, a haloalkyl, a dienophile, an aldehyde, a substituted ketone, a sulfonyl halide, a thiol, amino, an alkene, an alkyne, a halogen, a hydrazide, azido, imido, a ketene, an isocyanate, an epoxide, a maleimide, a 1,2,4,5-tetrazine derivative, a cycloalkyne derivative, a cycloalkene, a triphosphate, and a phosphoramidite, or any functional group substituted with the functional group,
- (3) a reactive group capable of covalent bonding with a functional group selected from carboxyl, a carboxyl derivative, hydroxyl, a haloalkyl, a dienophile, an aldehyde, a substituted ketone, a sulfonyl halide, a thiol, a substituted or unsubstituted amino, an alkene, an alkyne, a halogen, a hydrazide, azido, imido, a ketene, an isocyanate, an epoxide, a maleimide, a 1,2,4,5-tetrazine derivative, a cycloalkyne derivative, a cycloalkene, a triphosphate, and a phosphoramidite, or any functional group substituted with the reactive group, or
- (4) a protecting group selected from an alcohol-derived protecting group, an amine-derived protecting group, a carbonyl-derived protecting group, a carboxylic acid-derived protecting group, a phosphate-derived protecting group, and an alkyne-derived protecting group, or any functional group substituted with the protecting group,
- m and n are each independently 0 or 1, and
- Re and Rf of at least one of X1 to X6 are not hydrogen and deuterium.
9 more elements
Dependencies are inferred from the claim text.