Microbes and methods for selective detoxification of lignocellulosic biomass

A recombinant microorganism comprising one or more modifications with respect to a corresponding microorganism not comprising the one or more modifications, wherein the one or more modifications comprise 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 6 or more, 7 or more, 8 or more, 9 or more, 10 or more, 11 or more, 12 or more, 13 or more, 14 or more, or each of:

• a functional deletion of a glucokinase gene present in the corresponding microorganism;
• a functional deletion of a quinoprotein glucose dehydrogenase gene present in the corresponding microorganism;
• a functional deletion of a carbohydrate transporter gene present in the corresponding microorganism;
• a recombinant gene encoding HmfA of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfB of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfC of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfD of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfE of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfT1 of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfF of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfG of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfH′ of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfH of Cupriavidus basilensis or a homolog thereof;
• a recombinant gene encoding HmfS of Cupriavidus basilensis or a homolog thereof;
• and
• a recombinant gene encoding HmfT2 of Cupriavidus basilensis or a homolog thereof.