Precursory regulatory cytotrophoblast cells and uses thereof
AssigneeAccelerated Biosciences Corp.
InventorsJau-Nan Lee, Yuta Lee, Tony Tung-Yin Lee
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Abstract
Disclosed herein are precursory regulatory cytotrophoblast cells produced in vitro and compositions thereof. Disclosed herein are isolated populations of precursory regulatory cytotrophoblast cells, wherein the cells are produced in vitro. Disclosed herein are genetically engineered cells. Also disclosed herein are methods of treating a disorder or condition by utilizing the cells disclosed herein.
Claims21
An isolated precursory regulatory cytotrophoblast (prCTB), wherein:
- the prCTB expresses beta-hormone human chorionic gonadotropin (β-hCG), human leukocyte antigen G (HLA-G), CD56, insulin, heat shock protein 90 (HSP90), CD4, CD16, CD107a, CD8, leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1), leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2), T cell receptor (TCR), killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), programmed death-ligand 1 (PD-L1), apoptosis signal receptor (Fas), Fas Ligand (FasL), p53, Ki67, glutamate decarboxylase 65 (GAD65), and heat shock protein 70 (HSP70).
A composition, comprising a chemokine, an interleukin, a growth factor, or any combination thereof, and a pharmaceutically or cosmetically acceptable excipient, and wherein the composition is free from a cell.
A method of obtaining precursory regulatory cytotrophoblasts (prCTBs), comprising differentiating human trophoblast stem cells in vitro by contacting the human trophoblast stem cells with a fibroblast growth factor and a culture medium comprising nucleosides, L-glutamine, a dipeptide comprising L-glutamine, platelet lysate, or a combination thereof.
Dependencies are inferred from the claim text.