Humanized anti-egfr viii antibodies and antigen-binding fragments thereof
AssigneeNational Research Council of Canada
InventorsAnne MARCIL, Maria JARAMILLO, Traian SULEA, Maria MORENO, Cunle WU
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Abstract
Antigen-binding agents such as humanized antibodies or antigen-binding fragments thereof, that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRVIII-specific humanized antibodies or antigen-binding fragments thereof may be used for the treatment of cancer.
Claims47
An antigen-binding agent, antigen-binding domain, antibody or antigen-binding fragment thereof that specifically binds to epidermal growth factor receptor variant III (EGFRvIII), wherein the antigen-binding agent, antigen-binding domain, antibody or antigen-binding fragment comprises:
- a. a heavy chain variable region comprising the amino acid sequence QVQLQESGPGLVKPSQTLSLTCTVSGYSITSDYAWNWIRQPPGKGLEWX1GYI GYNGRTSYNPSLKSRX2TISX3DTSKNQFSLKLSSVTAADTAVYYCARLGRGFAY WGQGTLVTVSS (SEQ ID NO:3), where X1=I or M, X2=V or I, and X3=V or R;
- and,
- b. a light chain variable region comprising the amino acid sequence DIQMTQSPSSLSASVGDRVTITCHASQGINSNIGWX4QQKPGKAX5KX6LIYHGT NLEDGVPSRFSGSGSGTDYTLTISSLOPEDFATYYCVQYAQFPYTFGQGTKLEI K (SEQ ID NO:4), where X4=Y or L, X5=P or F, and X6=L or G.
The method of any one of claims 31 to 47, wherein the cells are immune cells autologous to the subject.
Dependencies are inferred from the claim text.