Polycyclic compounds as soluble epoxide hydrolase inhibitors

A compound of formula (I)

• or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein:
• G1 represents an oxygen atom or a methylene group or a single bond;
• G2 represents an oxygen atom or a sulphur atom;
• G3 represents a radical selected from the group consisting of —NH—(CH2)m—, —O—(CH2)m- and —(CH2)n—;
• m is an integer from 0 to 6;
• n is an integer from 1 to 7
• R1 is a radical selected from the group consisting of:
• a) C6-C10 aryl which may be optionally substituted by 1 to 4 substituents selected from the group consisting of halogen atoms, C1-C6 acyl, nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SF5), sulfonyl (SO3H), fluorosulfonyl (SO2F), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkoxycarbonylmethyl and methylaminocarbonylpyridyloxy;
• b) heteroaryl having from 2 to 11 carbon atoms and 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S and which may be optionally substituted by 1 to 4 substituents selected from the group consisting of halogen atoms, C1-C6 acyl, nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SF5), sulfonyl (SO3H), fluorosulfonyl (SO2F), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl and C1-C6 alkoxycarbonylmethyl;
• c) saturated or partially unsaturated, monocyclic or bicyclic heterocyclyl having from 5 to 11 carbon atoms and 1, 2 or 3 heteroatoms selected from the group consisting of N, O and S and which may be optionally substituted by 1 to 4 substituents selected from the group consisting of halogen atoms, C1-C6 acyl, C3-C6 cycloalkyl-C(═O), nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethylcarbonyl (CF3CO), pentafluorosulfanyl (SF5), sulfonyl (SO3H), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkoxycarbonylmethyl, C1-C6 alkylsulfonyl, C3-C6 cycloalkylsulfonyl, benzyl, heteroarylmethyl, pyridincarbonyl, phenylcarbonyl, tetrahydropyrancarbonyl, C6-C10 arylsulfonyl which may be optionally substituted by 1 to 2 substituents selected from the group consisting of halogen atoms, nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SF5), sulfonyl (SO3H), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkoxycarbonylmethyl and phenyl which may be optionally substituted by 1 to 4 substituents selected from the group consisting of halogen atoms, C1-C6 acyl, nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SF5), sulfonyl (SO3H), fluorosulfonyl (SO2F), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, C3-C6 cycloalkyl and C1-C6 alkoxycarbonylmethyl;
• d) C6-C10 cycloalkyl which may be optionally substituted by 1 to 4 substituents selected from the group consisting of halogen atoms, C1-C6 acyl, nitro (NO2), cyano (C≡N), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SF5), sulfonyl (SO3H), carboxylic group (COOH), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkoxycarbonylmethyl, pyridinyloxy which may be unsubstituted or substituted by a group selected from COOH and CONHCH3, and phenoxy which may be unsubstituted or substituted by COOH, COOR5, CONH2, CN or OH;
• R2 is a radical selected from the group consisting of hydrogen or deuterium atoms, halogen atoms, methyl, hydroxy and C1-C6 alkoxy;
• R3 and R4 are radicals which may be identical or different and which are independently selected from the group consisting of hydrogen atoms, halogen atoms, C1-C6 acyl, nitro (NO2), cyano (C≡N), carboxylic group (COOH), hydroxy (OH), trifluoromethyl (CF3), trifluoromethoxy (OCF3), pentafluorosulfanyl (SFs), sulfonyl (SO3H), fluorosulfonyl (SO2F), amino (NH2), mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C1-C6 alkoxy, C1-C6 alkyl and C1-C6 alkoxycarbonylmethyl;
• or R3 and R4 may form together a radical —O—(CH2)p-O—, wherein p is an integer from 1 to 3;
• R5 is a radical selected from C1-C6 alkyl and C3-C6 cycloalkyl.