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AssigneeChristian-Albrechts-Universität zu Kiel
InventorsRainer Herges, Arne Brahms, Andrey Pravdivtsev, Jan-Bernd Hövener
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A process for producing vinyl esters of carboxylic acids, especially vinyl esters of ketocarboxylic acids, which can be α-ketocarboxylic acids or β-ketocarboxylic acids. The vinyl esters of the carboxylic acids in their vinyl group can have hydrogen and have preferably deuterium in their vinyl group. The vinyl esters can be hydrogenated with para-hydrogen and the spin of the para-hydrogen can be transferred to the carbonyl carbon atom of the carboxyl group, which carbonyl-carbon atom is a 13C, followed by hydrolysis of the ester group, producing carboxylic acids, especially ketocarboxylic acids having a hyperpolarized 13C in the carbonyl carbon atom of the carboxyl group.
A process for producing a ketocarboxylic acid vinyl ester by reacting a carboxylic acid halogenide of the ketocarboxylic acid with a trialkyl silylenolether.
A process for producing a ketocarboxylic acid vinyl ester by reacting a carboxylic acid with deuterated alkenyl vinyl boronic ester in the presence of a metal catalyst.
A process for para-hydrogenating a ketocarboxylic acid vinyl ester, in which the vinyl moiety is fully deuterated and/or in which the ketocarboxylic acid moiety is fully deuterated, by reacting the ketocarboxylic acid vinyl ester within a solvent in the presence of a para-hydrogenation catalyst having formula I
Vinyl ester of a ketocarboxylic acid having the structures:
Dependencies are inferred from the claim text.