Extra-lumen adsorption of viral pathogens from blood
AssigneeSigyn Therapeutics, Inc.
InventorJames A. Joyce
Life of this patent
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Abstract
The device described herein converges the plasma separation function of a hollow-fiber plasmapheresis device with a formulation or cocktail of two or more adsorbent components housed in the extra-lumen space (outside the fiber walls, yet inside the outer shell of the plasmapheresis device) to optimize the adsorption of viral pathogens, shed viral proteins and viral exosomes (collectively known as the Viral Targets) in a low-shear force environment without interacting with blood cells.
Claims20
A method for treating a viral infection in an individual in need thereof, comprising:
- providing an extracorporeal adsorptive viral target removal device, said device having:
- a housing;
- a hollow fiber plasma filter having a plurality of pores sized between 200-2000 Angstroms and
- an adsorbent positioned inside the housing and outside the fiber in an extra lumen space;
- filtering the plasma of an individual in need thereof through said adsorptive viral target removal device;
- wherein said filtering causes a viral target to pass through said pores;
- contacting said viral target with said adsorbent;
- wherein said viral target is bound to said adsorbent;
- and
- capturing said viral target in said adsorbent.
A kit for treating a viral infection in an individual in need thereof, the kit comprising:
- a broad spectrum extracorporeal blood purification device, comprising
- a housing;
- a hollow fiber filter disposed within said housing, said filter comprising a plurality of pore sized and dimensioned to permit passage of viral targets having a diameter between about 20 nm and 200 nm;
- and
- at least one adsorption component positioned inside the housing and outside the hollow fiber in an extra-lumen space.
Dependencies are inferred from the claim text.