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US 2024/0398994 A1Published application
Viral Vectors for Cancer Therapy
AssigneeKrystal Biotech, Inc.
InventorsSuma Krishnan, Trevor Parry, Dana Michelle Previte, Mary Jane Duermeyer
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Abstract
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.
Claims31
1-83. (canceled)
A pharmaceutical composition comprising:
- (a) a herpes simplex virus comprising a recombinant herpes simplex virus genome, wherein the recombinant herpes simplex virus genome comprises a first polynucleotide encoding an Interleukin (IL)-12 polypeptide and a second polynucleotide encoding a cytokine or a chemokine;
- and
- (b) a pharmaceutically acceptable excipient,
- wherein the IL-12 polypeptide comprises an IL-12 subunit alpha polypeptide and an IL-12 subunit beta polypeptide connected by a linker polypeptide, and
- wherein the recombinant herpes simplex virus genome further comprises a first promoter operably linked to the first polynucleotide encoding the IL-12 polypeptide and a second promoter operably linked to the second polynucleotide encoding the cytokine or the chemokine.
2 more elements
A pharmaceutical composition comprising:
- (a) a herpes simplex virus comprising a recombinant herpes simplex virus genome, wherein the recombinant herpes simplex virus genome comprises a first polynucleotide encoding an IL-2 polypeptide and a second polynucleotide encoding a cytokine or a chemokine;
- and
- (b) a pharmaceutically acceptable excipient,
- wherein the recombinant herpes simplex virus genome further comprises a first promoter operably linked to the first polynucleotide encoding the IL-2 polypeptide and a second promoter operably linked to the second polynucleotide encoding the cytokine or the chemokine.
1 more element
Dependencies are inferred from the claim text.