Nematode vaccine
AssigneeAgResearch Limited
InventorsSaleh UMAIR, Jacqueline Sarah KNIGHT
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Abstract
The present invention is directed to a vaccine comprising recombinant antigens derived from the parasitic nematode Haemonchus contortus, which will raise an immune response in farmed and wild ruminants that are susceptible or predisposed to infection by one or more nematode worm species. The recombinant antigens used in the invention are conserved among species of nematode worms so that the vaccine will provide protection against multiple types of nematode worms. In particular, the invention provides a composition or vaccine composition comprising the recombinant H. contortus antigens: (i) enolase (EN); (ii) arginine kinase (AK); and (iii) ornithine decarboxylase (ODC), or antigenic fragments thereof, together with a veterinary acceptable carrier or diluent.
Claims20
A composition or vaccine composition comprising the recombinant H. contortus antigens:
- (i) enolase (EN);
- (ii) arginine kinase (AK);
- and
- (iii) ornithine decarboxylase (ODC),
- or antigenic fragments thereof, together with a veterinary acceptable carrier or diluent.
A composition or vaccine composition comprising the H. contortus recombinant antigens:
- (i) enolase (EN);
- (ii) arginine kinase (AK);
- (iii) ornithine decarboxylase (ODC);
- (iv) seryl tRNA synthetase (SRS-2);
- (v) macrophage migration inhibitory factor 2 (MIF-2);
- (vi) fatty acid synthetase (FASN-1);
- (vii) NAD (P) H-dependant oxidoreductase (F36A2-3);
- (viii) glutamyl tRNA synthetase (ERS-2);
- (ix) aspartyl tRNA synthetase (DRS-1);
- (x) transcriptional co-activator (CBP-1);
- (xi) vacuolar ATPase (VHA-12);
- and
- (xii) serum-glucocorticoid-inducible kinase (SGK-1),
- or antigenic fragments thereof, together with a veterinary acceptable carrier or diluent.
A use of the recombinant H. contortus antigens (i) enolase (EN), (ii) arginine kinase (AK), and (iii) ornithine decarboxylase (ODC), or antigenic fragments thereof, in the manufacture of a composition or vaccine composition for reducing nematode parasitic worm burden in a farmed or wild ruminant animal.
A use of the recombinant H. contortus antigens (i) enolase (EN), (ii) arginine kinase (AK), and (iii) ornithine decarboxylase (ODC), or antigenic fragments thereof in the manufacture of a composition or vaccine composition for stimulating or boosting acquired immunity in a farmed or wild ruminant animal to treat or protect said animal against infection by parasitic nematodes.
A use of the recombinant H. contortus antigens (i) enolase (EN), (ii) arginine kinase (AK), and (iii) ornithine decarboxylase (ODC), or antigenic fragments thereof, in the manufacture of a composition or vaccine composition for treating or preventing a nematode infection in a farmed or wild ruminant animal.
Dependencies are inferred from the claim text.