Plant messenger packs encapsulating polypeptides and uses thereof
AssigneeFlagship Pioneering Innovations VI, LLC
InventorsMaria Helena Christine VAN ROOIJEN, John Patrick CASEY, JR., Nataliya Vladimirovna NUKOLOVA, Simon SCHWIZER, Daniel Garcia CABANILLAS
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Abstract
Disclosed herein are plant messenger packs (PMPs) encapsulating one or more exogenous polypeptides. Also disclosed are methods of producing a PMP comprising an exogenous polypeptide.
Claims24
A plant messenger pack (PMP) comprising one or more exogenous polypeptides, wherein the one or more exogenous polypeptides are mammalian therapeutic agents and are encapsulated by the PMP, and wherein the exogenous polypeptides are not pathogen control agents.
(canceled)
(canceled)
A composition comprising a plurality of PMPs, wherein each of the PMPs is a plant EV, or a segment or extract thereof, wherein each of the plurality of PMPs encapsulate an exogenous polypeptide, wherein the exogenous polypeptide is a mammalian therapeutic agent, the exogenous polypeptide is not a pathogen control agent, and the composition is formulated for delivery to an animal.
22-25. (canceled)
A method of producing a PMP comprising an exogenous polypeptide, wherein the exogenous polypeptide is a mammalian therapeutic agent, and wherein the exogenous polypeptide is not a pathogen control agent, the method comprising:
- (a) providing a solution comprising the exogenous polypeptide;
- and
- (b) loading the PMP with the exogenous polypeptide, wherein the loading causes the exogenous polypeptide to be encapsulated by the PMP.
27-30. (canceled)
Dependencies are inferred from the claim text.