Phenylcoumarins for treating inflammation
AssigneeOhio State Innovation Foundation
InventorsEsperanza CARCACHE DE BLANCO, Nicole A. WOODARD, Gerardo David ANAYA EUGENIO, Rachel MATA, Isabel RIVERO CRUZ
Life of this patent
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Abstract
The present disclosure is directed to compounds of Formula I, compositions, and methods of using the same in the treatment or prevention of inflammation or disorders or conditions associated with the same comprising administering a therapeutically effective amount of a compound described herein, or a pharmaceutically acceptable salt, prodrug, or derivative thereof.
Claims31
A compound of Formula I:
- or a pharmaceutically acceptable salt, prodrug, or derivative thereof,
- wherein:
- R1 is
- R2, R3, and R4 are each independently selected from hydrogen, halo, cyano, azido, C1-C6alkyl, C1-C6haloalkyl, RxO-, and RxRyN-, wherein R3 and R4 cannot both hydroxyl;
- Rx and Ry are independently selected at each occurrence from hydrogen, C1-C6alkyl, C1-C6haloalkyl, C2-C6alkenyl, C2-C6alkynyl, (C3-C7cycloalkyl)-(C0-C3 alkyl)-, (4- to 6-membered heterocycle)-(C0-C3 alkyl)-, (5- to 10-membered monocyclic or bicyclic aryl)-(C0-C3 alkyl)-, (5- to 10-membered monocyclic or bicyclic heteroaryl)-(C0-C3 alkyl)-, each of which may be optionally substituted with one or more Y groups as allowed by valency;
- and
- Y is independently selected at each occurrence from alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycle, aldehyde, amino, carboxylic acid, ester, ether, halo, hydroxy, keto, nitro, cyano, azido, oxo, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, sulfonylamino, or thiol.
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A method for treating inflammation or for diminishing or ameliorating one or more symptoms caused by inflammation in a subject in need thereof comprising administering a therapeutically effective amount of a compound of Formula II
- or a pharmaceutically acceptable salt, prodrug, or derivative thereof.
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A method for the treatment or for ameliorating or diminishing one or more inflammatory symptoms of a systemic inflammatory disorder in a subject in need thereof comprising administering a therapeutically effective amount of a compound of Formula II
- or a pharmaceutically acceptable salt, prodrug, or derivative thereof.
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Dependencies are inferred from the claim text.