Package and method for producing the same
AssigneeSeikagaku Corporation
InventorMine HIGUCHI
Life of this patent
Estimating the term…
Abstract
There is provided a package wherein a pharmaceutical composition containing a saccharide-degrading enzyme is contained in a container, whereby reduction in titer caused by a low amount of enzyme is suppressed. A package comprising a pharmaceutical composition and a container, wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient, and the container contains the pharmaceutical composition, the inner surface of the container comprising at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins.
Claims14
A package comprising
- a pharmaceutical composition, and
- a container,
- wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient,
- wherein the container contains the pharmaceutical composition and comprises at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins, at an inner surface of the container,
- wherein the saccharide-degrading enzyme is chondroitinase ABC, and
- wherein an enzyme activity per the container is less than 4 units.
A package comprising
- a pharmaceutical composition, and
- a container,
- wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient,
- wherein the saccharide-degrading enzyme is chondroitinase ABC,
- wherein an enzyme activity per the container is less than 4 units,
- wherein the enzyme has a titer of not less than 0.3 unit/μg,
- wherein the container comprises a film containing silicon dioxide on the inner surface of the container, and
- wherein the film is formed by plasma chemical vapor deposition.
A method for producing a pharmaceutical composition contained in a container, the method comprising:
- putting a solution comprising a saccharide-degrading enzyme into the container, the container comprising at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins, at an inner surface of the container, and
- lyophilizing the solution,
- wherein the saccharide-degrading enzyme is chondroitinase ABC, and
- wherein an enzyme activity per the container is less than 4 units.
A method for producing a pharmaceutical composition contained in a container, the method comprising:
- putting a solution comprising a saccharide-degrading enzyme into the container,
- wherein the saccharide-degrading enzyme is chondroitinase ABC,
- wherein an enzyme activity per the container is less than 4 units.
- wherein the enzyme has a titer of not less than 0.3 unit/μg,
- wherein the container comprises a film containing silicon dioxide on the inner surface of the container, and
- wherein the film is formed by plasma chemical vapor deposition.
Dependencies are inferred from the claim text.