Methods for assessing treatment with a gastrointestinal implant
AssigneeMorphic Medical, Inc.
InventorScott SCHORER
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Abstract
The present invention provides methods of predicting and monitoring treatment with a gastrointestinal implant (e.g., a gastrointestinal sleeve), including efficacy and complications associated therewith (e.g., complications attributed to the gastrointestinal implant or occurring concurrently with, but independent from, the gastrointestinal implant). Further provided are methods of determining a time point for removing a gastrointestinal implant (e.g., based on one or more biomarkers, e.g., biomarkers associated with safety and efficacy).
Claims134
A method for assessing risk of complication in an individual as a result of treatment with a gastrointestinal implant, the method comprising:
- (a) providing a level of one or more biomarkers in a sample from the individual, wherein the level of the one or more biomarkers in the sample indicates whether the individual is at risk of complication as a result of treatment with a gastrointestinal implant, and
- (b) determining a treatment based on the level of the one or more biomarkers.
A method for assessing risk of complication in an individual as a result of treatment with a gastrointestinal implant, the method comprising:
- (a) providing a level of one or more biomarkers in a sample from the individual during treatment with a gastrointestinal implant, wherein the level of the one or more biomarkers in the sample indicates whether the individual is at risk of complication as a result of treatment with a gastrointestinal implant, and
- (b) determining a subsequent treatment based on the level of the one or more biomarkers.
A method for determining whether an individual is a candidate for treatment with a gastrointestinal implant, the method comprising:
- (a) providing a level of one or more biomarkers in a sample from the individual, wherein the level of the one or more biomarkers in the sample indicates whether the individual is a candidate for treatment with the gastrointestinal implant, and
- (b) determining that the individual is a candidate for the treatment with the gastrointestinal implant based on the level of the one or more biomarkers.
A method for assessing risk of intestinal barrier permeability in an individual as a result of treatment with a gastrointestinal implant, the method comprising administering one or more diagnostic markers indicative of intestinal barrier permeability.
The method of any one of 1-112, wherein the gastrointestinal implant is configured for implantation within a gastrointestinal tract at or distal to the pylorus of the individual.
A method for determining a time point for removing a gastrointestinal implant from an individual, the method comprising:
- (a) providing a safety parameter and/or an efficacy parameter for an individual undergoing treatment with a gastrointestinal implant;
- (b) based on the safety parameter and/or the efficacy parameter, calculating a removal score;
- and
- (c) based on the removal score, determining a time point for removing the gastrointestinal implant from the individual.
A method for determining a time point for removing a gastrointestinal implant from an individual, the method comprising:
- (a) providing a safety parameter and/or an efficacy parameter for an individual undergoing treatment with a gastrointestinal implant;
- (b) based on the safety parameter, the efficacy parameter, and/or a normal peak inflammatory period, calculating a removal score;
- and
- (c) based on the removal score, determining a time point for removing the gastrointestinal implant from the individual.
Dependencies are inferred from the claim text.