Method and compact marker for marking a biological sample

Abstract

A method for marking a biological sample includes providing a biological sample with at least one first target analyte, introducing into the biological sample at least one first nucleic acid backbone, at least one first label configured to attach to the first nucleic acid backbone, and at least one first affinity reagent specific to the first target analyte and configured to attach to the first nucleic acid backbone, and introducing into the biological sample a first plurality of staple strands. Each staple strand of the first plurality of staple strands is configured to hybridise to pairs of folding binding sites of the first nucleic acid backbone, in order to fold the first nucleic acid backbone and generate a compact optically detectable first marker in the biological sample.

Dependencies are inferred from the claim text.