Wireless Power-up and Readout of Label-free Electronic Detection of Protein Biomarkers

A measurement system for detecting a target analyte in a sample, the system comprising:

• a nanowell impedance sensor configured to receive a sample including a target analyte, an impedance between electrodes of the sensor being modulated by the target analyte when the target analyte is present in the sample, the modulated impedance being indicative of a concentration of the target analyte in the sample;
• a receiver circuit connected across the electrodes and having a receiver resonance frequency, the receiver circuit including an inductive coil;
• and
• a transmitter circuit having a transmitter resonance frequency such that the receiver resonance frequency is within a resonance overlap percentage of the transmitter resonance frequency, the transmitter circuit including:
• a voltage source configured to apply an electrical voltage to the inductive coil of the transmitter circuit, so as to induce the electrical current in the receiver circuit, causing an electrical voltage to be applied across the electrodes of the nanowell sensor;
• and
• an inductive coil configured to be wirelessly coupled with the inductive coil of the receiver circuit by mutual inductance such that the receiver circuit is inductively coupled with the transmitter circuit;
• wherein:
• the electrical current induced in the receiver circuit is a time-varying signal having a frequency within a signal overlap percentage of the receiver resonance frequency;
• and
• the modulated impedance is determined as a function of the electrical current induced, thereby detecting the presence of the target analyte, and the concentration thereof, in the sample.