Methods of mass spectrometry, a mass spectrometer and computer software
AssigneeThermo Fisher Scientific (Bremen) GmbH
InventorsHamish Stewart, Alexander Makarov
Life of this patent
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Abstract
A method of mass spectrometry is provided. The method comprises performing the following steps for each of a plurality of sub-ranges selected from an overall m/z range: accumulating in an ion store a sample of precursor ions to be analysed, the precursor ions having m/z values within the sub-range; accumulating in the ion store a sample of fragmented precursor ions to be analysed, the fragmented precursor ions being formed from fragmentation of precursor ions having m/z values within the sub-range; and simultaneously analysing the combined samples of the precursor ions and the fragmented precursor ions in a mass analyser.
Claims22
A method of mass spectrometry comprising the steps of:
- for each of a plurality of sub-ranges selected from an overall m/z range:
- accumulating in an ion store a sample of precursor ions to be analysed, the precursor ions having m/z values within the sub-range;
- accumulating in the ion store a sample of fragmented precursor ions to be analysed, the fragmented precursor ions being formed from fragmentation of precursor ions having m/z values within the sub-range;
- and
- simultaneously analysing the combined samples of the precursor ions and the fragmented precursor ions in a mass analyser.
A method of mass spectrometry comprising the steps of:
- for each of a plurality of sub-ranges selected from an overall m/z range:
- configuring an ion filter to transmit precursor ions having m/z values within the sub-range;
- analysing a sample of the precursor ions received from the configured ion filter in a mass analyser;
- and
- analysing a sample of fragment ions that are produced by fragmenting precursor ions received from the configured ion filter in the mass analyser.
A method of mass spectrometry comprising the steps of:
- analysing a sample of precursor ions having m/z values from an overall m/z range in a mass analyser, wherein analysing the sample of precursor ions having m/z values from the overall m/z range comprises obtaining scan data for the overall m/z range;
- identifying one or more precursor ion species for further analysis, based on the scan data;
- for each of the one or more identified precursor ion species:
- accumulating a sample of fragmented precursor ions in an ion store, wherein the sample of fragmented precursor ions comprises ions formed from fragmentation of precursor ions of the identified precursor ion species;
- and
- identifying a related precursor ion species and accumulating a sample of precursor ions of the related precursor ion species in the ion store;
- simultaneously analysing the combined samples of the precursor ions and the fragmented precursor ions in a mass analyser.
Dependencies are inferred from the claim text.