Zwitterionic surfaces for localized surface plasmon resonance
AssigneeThe Trustees of Indiana University
InventorsRajesh SARDAR, Barry B. MUHOBERAC, Adrianna N. MASTERSON, Sumon HATI
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a plasmonic molecular device consisting photoisomerizable molecular switch-tethered gold triangular nanoprisms and methods for using such device for the detection of biomarkers. The molecular device exhibits unprecedentedly large localized surface plasmon resonance shifts during the photoisomerization of molecular switches. The fabricated molecular device with zwitterionic structure has been utilized to develop adaptable nanoplasmonic biosensor for ultrasensitive. highly specific and programmable detection of microRNAs and proteins from patient biofluids.
Claims20
An adaptable nanoplasmonic biosensor for specific detection of target proteins and nucleic acids, said biosensor comprising
- a localized surface plasmon resonance (LSPR) chip having an affixation surface and a functional surface;
- a functionalized solid support;
- and
- an LSPR antennae comprising a light inducible isomerizable compound, wherein
- said affixation surface of the LSPR chip is covalently linked to said solid support, and said LSPR antennae is linked to said functional surface of the LSPR chip.
Dependencies are inferred from the claim text.