Ligand conjugates for delivery of therapeutically active agents

A compound having the structure shown in Formula (I)

• or a pharmaceutically acceptable salt or solvate thereof, wherein
• A and B, for each occurrence, are each independently O, N(RN), or S;
• RN is H or C1-6 alkyl;
• X and W, for each occurrence, are each independently H, a protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a polymer, a nucleotide, a nucleoside, an oligonucleotide, or a therapeutically active agent;
• Z′ and Z″ are each independently O or S;
• L is a covalent linker;
• Z is a carbohydrate mimetic or a disaccharide, trisaccharide, or oligosaccharide;
• each Y is independently -L′-T;
• each T is independently a ligand selected from the group consisting of carbohydrate ligands, polypeptide ligands, and lipophile ligands;
• each L′ is independently a covalent linker;
• and
• p and q are each independently 1, 2, 3, 4, or 5.