US 2024/0392233 A1 · LACTIC ACID BACTERIA FOR MODULATING BODY OXYGENATION AND METHODS FOR USING SAME

Abstract

The invention relates to particular species, strains, and compositions of lactic acid bacteria capable of increasing cellular levels of the hypoxia-inducible factor HIF-1α for the maintenance or enhancement of normoxia in hypoxia-inducing conditions such as, for example, physical exertion, lethargy, chronic fatigue, oxygen deficiency, travel beyond the limits of the earth's atmosphere, oxidative stress of eyeballs and scuba diving, or for the treatment of hypoxia in hypoxia-inducing conditions such as neurodegenerative diseases, pulmonary implications associated with respiratory failure, neonatal hypoxia-ischemia, myocardial ischemia, metabolic disorders, chronic cardiac and renal diseases, reproductive disorders such as pre-eclampsia and endometriosis, exacerbation of postural and kinetic tremors, and cerebral hypoxia.

Claims16

Dependent claims

An isolated strain of Lactobacillus acidophilus deposited under the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having the accession number CNCM I-5567,
wherein the strain of Lactobacillus acidophilus is capable of increasing cellular levels of the hypoxia-inducible factor HIF-1α associated with the reduction of cellular oxygen consumption for use in the treatment of hypoxia in hypoxia-inducing conditions selected from the group consisting of chronic fatigue, oxygen deprivation, neurodegenerative diseases, neonatal hypoxia-ischemia, myocardial ischemia, metabolic disorders, chronic cardiac and renal diseases, reproductive disorders such as pre-eclampsia and endometriosis, exacerbation of postural and kinetic tremors, and cerebral hypoxia.

The composition of claim 2, further comprising:
(a) a strain of Streptococcus thermophilus deposited pursuant to the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having the access number CNCM I-5570,
(b) a strain of Bifidobacterium animalis subsp. lactis deposited pursuant to the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having access number CNCM I-5571,
(c) a strain of Bifidobacterium animalis subsp. lactis deposited under the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having access number CNCM I-5572, or
(d) a strain of Levilactobacillus brevis deposited under the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having the accession number CNCM I-5566,
(e) a strain of Lactiplantibacillus plantarum subsp. plantarum deposited under the Budapest Treaty on Sep. 1, 2020 at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having accession number CNCM I-5569,
(f) a strain of Lacticaseibacillus paracasei subsp. paracasei deposited under the Budapest Treaty on Sep. 1, 2020, at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having accession number CNCM I-5568,
(g) a strain of Lactobacillus helveticus deposited under the Budapest Treaty on Sep. 1, 2020, at the Collection Nationale de Cultures de Microorganismes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, and having accession number CNCM I-5573, or
(h) any combination of (a), (b), (c), (d), (e), (f) or (g).

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Lactic acid bacteria for modulating body oxygenation and methods for using same

Life of this patent

Lactic acid bacteria for modulating body oxygenation and methods for using same

Life of this patent

Abstract

Claims16