Antibody-drug conjugate conjugated via breakable linker

Abstract

Provided is an antibody-drug conjugate based on a microtubule inhibitor. Specifically provided are a compound as represented by formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a solvate of the compound, the pharmaceutically acceptable salt thereof or the stereoisomer thereof. The present invention further relates to an antibody-drug conjugate formed by means of connecting a targeting moiety with the compound as represented by formula (I), the pharmaceutically acceptable salt thereof, the stereoisomer thereof, or the solvate of the compound, the pharmaceutically acceptable salt thereof or the stereoisomer thereof via a thioether bond. MC—L1—L2—D   (I)

Dependencies are inferred from the claim text.