Heterodimeric protein and application thereof

Abstract

In the field of biomedicine, a heterodimeric protein and application thereof. The heterodimeric protein includes: (1) a light chain and a first heavy chain, where the light chain and the first heavy chain are combined to form a targeting moiety that exhibits binding specificity to a tumor antigen or an immune checkpoint, and the tumor antigen or the immune checkpoint includes B7H3; (2) a second heavy chain, wherein the second heavy chain includes a Fc region and an immunomodulator fused to the Fc region, and the immune regulator includes IL-10. The results of affinity test showed that the heterodimeric protein had high affinity for B7H3 and IL-10 receptors. The results of pharmacodynamic experiments in vivo showed that the heterodimeric protein had good anti-tumor activity.

Dependencies are inferred from the claim text.