Methods of treating cancers associated with immunosuppressive b cells
AssigneeBiograph 55, Inc.
InventorsLeonard PRESTA, Paul TUMEH, Nils LONBERG, Omar DURAMAD
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Abstract
Described herein is a method of treating a cancer or tumor associated with CD19 positive, CD38 positive, CD20 negative immunosuppressive B cells in an individual comprising administering to the individual a bispecific antibody that binds CD19 and CD38, thereby treating the cancer or tumor associated with CD19 positive, CD38 positive, CD20 negative immunosuppressive B cells.
Claims81
A method of treating a cancer or tumor associated with CD19 positive, CD38 high immunosuppressive B cells in an individual comprising administering to the individual a bispecific antibody that binds CD19 and CD38, thereby treating the cancer or tumor associated with CD19 positive, CD38 high immunosuppressive B cells.
A method of treating an individual afflicted with a tumor or cancer, the method comprising performing an assay on the B cells of a biological sample of the individual for a CD38 high phenotype;
- and administering a bispecific antibody that binds CD19 and CD38 to the individual afflicted with the tumor or the cancer based on results of the assay on the B cells of a biological sample from the individual.
A method of treating an individual afflicted with a tumor or cancer, the method comprising administering a bispecific antibody that binds CD19 and CD38 to the individual afflicted with the tumor or the cancer based on results of an assay on B cells of a biological sample of the individual.
Dependencies are inferred from the claim text.