Bi-functional fusion protein and uses thereof
AssigneesNan TANG, Pulmongene (Hong Kong) Co., Limited
InventorsNan TANG, Jianhua SUI, Ximing LIU, Nanmeng SONG, Rui ZHAO
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Abstract
Provided is a bi-functional fusion protein that targets both TGFβ ligands and AREG, and blocks TGFβ and AREG signaling simultaneously, as well as a nucleic acid molecule encoding the bi-functional fusion protein, an expression vector for producing the bi-functional fusion protein, a host cell for producing the bi-functional fusion protein, and a method for preparing and/or characterizing the bi-functional fusion protein.
Claims30
A bi-functional fusion protein comprising a first domain and a second domain, wherein
- the first domain is capable of binding to AREG or a fragment thereof, preferably is an antibody or an antigen-binding fragment thereof that binds to AREG or a fragment thereof, and
- the second domain is capable of binding to a TGFβ ligand or a fragment thereof, preferably comprises a part of the ectodomain of TGFβ receptor II (TRII) or a variant thereof.
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Dependencies are inferred from the claim text.