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US 2024/0391972 A1Published application
Il-12 and il-15 polypeptides
AssigneeSagittarius Bio, Inc
InventorsKayvan NIAZI, Shahrooz RABIZADEH
Life of this patent
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Abstract
The present application provides for polypeptides comprising an IL-12 polypeptide, and/or a IL-15 polypeptide, and/or a IL-15 receptor polypeptide, compositions comprising the same, and methods of using the same.
Claims111
A polypeptide comprising the formula of:
- X1-L1-X2-L2-X3-L3-X4, wherein:
- X1 is a interleukin 15 (IL-15) polypeptide, interleukin 12 p40 subunit (IL-12 p40) polypeptide, interleukin 12 p35 subunit (IL-12 p35) polypeptide, or interleukin 15 receptor (IL-15Ra) polypeptide;
- X2 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, or IL-15Ra polypeptide;
- X3 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, or IL-15Ra polypeptide;
- X4 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, or IL-15Ra polypeptide;
- L1, L2, and L3 are each, independently, a polypeptide linker that comprise the same or different polypeptide sequences,
- provided each of X1, X2, X3, and X4 are different.
4 more elements
A polypeptide comprising the formula of:
- X1-L1-X2-L2-X3-L3-X4-L4-X5, wherein:
- X1 is a interleukin 15 (IL-15) polypeptide, interleukin 12 p40 subunit (IL-12 p40) polypeptide, interleukin 12 p35 subunit (IL-12 p35) polypeptide, interleukin 15 receptor (IL-15Ra) polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X2 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X3 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X4 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X5 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- L1, L2, L3, and L4 are each, independently, a polypeptide linker that comprise the same or different polypeptide sequences,
- provided each of X1, X2, X3, X4, and X5 are different.
5 more elements
A polypeptide comprising the formula of:
- X1-L1-X2, wherein:
- X1 is a interleukin 15 (IL-15) polypeptide, interleukin 12 p40 subunit (IL-12 p40) polypeptide, interleukin 12 p35 subunit (IL-12 p35) polypeptide, or interleukin 15 receptor (IL-15Ra) polypeptide;
- X2 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, or IL-15Ra polypeptide;
- L1 is a polypeptide linker,
- provided X1 and X2 are different.
2 more elements
A polypeptide comprising the formula of:
- X1-L1-X2-L2-X3, wherein:
- X1 is a interleukin 15 (IL-15) polypeptide, interleukin 12 p40 subunit (IL-12 p40) polypeptide, interleukin 12 p35 subunit (IL-12 p35) polypeptide, interleukin 15 receptor (IL-15Ra) polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X2 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- X3 is a IL-15 polypeptide, IL-12 p40 polypeptide, IL-12 p35 polypeptide, IL-15Ra polypeptide, a first fragment of IL-15Ra polypeptide, or a second fragment of IL-15Ra polypeptide;
- L1 and L2 are each, independently, a polypeptide linker that comprise the same or different polypeptide sequences,
- provided each of X1, X2, and X3 are different.
3 more elements
The polypeptide of any one of claims 1-575, wherein one or more of L1, L2, L3, and L4 are each, independently, a cleavable linker.
Dependencies are inferred from the claim text.