Compositions and methods for the treatment of cancer
AssigneeThe University of Western Australia
InventorsPilar Blancaort, Ciara DUFFY
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Abstract
The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins αvβ6 and αvβ3. Preferably the RGD-motif containing fusion peptide can reduce viability of cancer cells, including in particular, TNBC and HER2-enriched breast cancer cells, and ovarian cancer cells.
Claims23
A fusion peptide comprising (1) SEQ ID NO:
- 1, or a variant thereof, and (2) an RGD-motif containing peptide, wherein the fusion peptide binds to the integrins αvβ6 and αvβ3.
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A fusion peptide comprising SEQ ID NO:
- 3, or a variant thereof.
A method of treating triple negative breast cancer, HER2 enriched breast cancer or ovarian cancer comprising the steps of:
- (1) administering a therapeutically effective amount of melittin;
- and (2) administering a therapeutically effective amount of docetaxel or cisplatin to a subject in need thereof.
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Dependencies are inferred from the claim text.