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AssigneeWaters Technologies Corporation
InventorsDaniel P. Walsh, Kevin Daniel Wyndham, Jacob Nathan Cairchild, Nicole L. Lawrence
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The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The chromatographic materials of the invention have controlled porosity and comprise a chromatographic core material and one or more layers of chromatographic surface materials which each independently provide an average pore diameter, an average pore volume, or a specific surface area such that the combined layers form a chromatographic material having a predetermined or desired pattern of porosity from the core material to the outermost surface. The materials are useful for HPLC separations, normal-phase separations, reversed-phase separations, chiral separations, HILIC separations, SFC separations, affinity separations, perfusive separations, partially perfusive separations, and SEC separations.
A chromatographic material comprising a chromatographic core material having a primary surface and a plurality of layers of a chromatographic surface material, wherein each layer of the plurality of layers of a chromatographic surface material independently has an average pore diameter of 20 to 1500 Angstroms, wherein the average pore diameter of each layer of the plurality of layers of the chromatographic surface material varies in a pattern with increasing distance from the primary surface of the chromatographic core material to the outermost surface of the chromatographic material, wherein the pattern is selected from the group consisting of a cone shape, a tapered shape, a fluted shape, a trumpeted shape and combinations thereof, wherein the pattern is defined by a plot of average pore diameter with increasing distance from the primary surface of the chromatographic core material proceeding to the outermost surface of the chromatographic material.
Dependencies are inferred from the claim text.