High-bandwidth systems for closed-loop spinal cord stimulation

A system for performing spinal cord stimulation on a patient, the system comprising:

• one or more recording arrays configured to be minimally invasively inserted to a target recording site of a brain of the patient, each recording array comprising a plurality of recording electrodes having a spacing of less than about 1 mm therebetween, each recording electrode having a diameter of less than about 1 mm and configured to record electrical signals from the target recording site;
• at least one stimulation array configured to be inserted to a target stimulation site proximate to nervous tissue of the patient, each stimulation array comprising a plurality of stimulation electrodes, each stimulation electrode configured to deliver electrical stimulation to the target stimulation site;
• one or more inertial sensors configured to detect at least one of an orientation and a movement state of the patient;
• a processor;
• and
• a non-transitory, computer-readable medium storing instructions that, when executed, cause the processor to:
• receive, via the one or more recording arrays, one or more recorded signals from the target recording site,
• determine an electrophysiological state of the brain based on at least the one or more recorded signals,
• receive one or more inertial signals from the one or more inertial sensors, determine the at least one of an orientation and a movement state of the patient based on the one or more inertial signals, and
• selectively deliver, via the at least one stimulation array, electrical stimulation to the target stimulation site based on one or more of the determined electrophysiological state and the determined at least one of an orientation and a movement state of the patient, wherein the electrical stimulation is configured to electrically stimulate the nervous tissue.