Pre-filled syringe with optimized stopper placement

A pre-filled syringe, comprising:

• a barrel having a first, proximal end and a second, distal end with a medicament disposed therein, wherein the medicament is a suspension of paliperidone palmitate, and the syringe has a nominal capacity of 5 mL;
• and
• a stopper disposed within the barrel adjacent the first end of the barrel, the stopper having a body with a distal end and a proximal end and having an outer sidewall extending therebetween, the outer sidewall having at least two adjacent sealing rings extending radially from a minor diameter of the body to a major diameter of the body,
• wherein for a presentation of the medicament having a volume of about 3.5 mL, the ratio of a target head space distance between a distal-most surface of the stopper and the surface of the medicament to the target volume of the presentation of the medicament is greater than about 0.86 mm/mL and less than about 2.00 mm/mL,
• wherein for a presentation of the medicament having a volume of about 5 mL, the ratio of the target head space distance between a distal-most surface of the stopper and the surface of the medicament to the target volume of the presentation of the medicament is greater than about 0.60 mm/mL and less than about 1.40 mm/mL, and,
• wherein the target head space distance between a distal-most surface of the stopper and the surface of the medicament (a) provides sufficient space to optimize reconstituting a drug suspension by shaking or agitating the drug suspension, and (b) minimizes frothing and/or clogging of the reconstituted drug suspension in the barrel.