Novel antibody sequences for diagnostics and therapeutics
AssigneeImaginab, Inc.
InventorsAlessandro MASCIONI, Fang JIA, Leticia Maria DE SOUZA CORDEIRO, Kelley C. ATKINSON, Patrick JOYCE, Argin AIVAZIAN, Zheng LIU, Ian Andrew WILSON
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Abstract
Aspects of the present disclosure relate generally to novel antigen binding sequences and uses thereof. More specifically, certain features of the present disclosure concern antibodies, minibodies, and cys-diabodies for use in targeting the protein FAP. The antigen binding sequences herein may be used as part of treatment to confer health benefits to subjects in need thereof. The antigen binding sequences can also be used for detection, targeting, and imaging purposes.
Claims21
1-54. (canceled)
An isolated antigen binding construct comprising:
- a HCDR1 comprising the amino acid sequence of SEQ ID NO:
- 81 (NYDIN), or a sequence that has no more than 3 point mutations thereto;
- a HCDR2 comprising the amino acid sequence of SEQ ID NO:
- 82 (LIWTGGGTN), or a sequence that has no more than 3 point mutations thereto;
- and/or
- a HCDR3 comprising the amino acid sequence of SEQ ID NO:
- 83 (GGPLVWYALDY), or a sequence that has no more than 3 point mutations thereto.
An isolated antigen binding construct, comprising:
- a HCDR1 comprising amino acids having at least 80% identity with the amino acid sequence of SEQ ID NO:
- 1 (EYTIH);
- a HCDR2 comprising amino acids having at least 80% identity with the amino acid sequence of SEQ ID NO:
- 2 (GINPNNGIPNYNQKFKG);
- a HCDR3 comprising amino acids having at least 80% identity with the amino acid sequence of SEQ ID NO:
- 3 (RRIAYGYDEGHAMDY);
- a LCDR1 comprising amino acids having at least 80% identity with the amino acid sequence of SEQ ID NO:
- 4 (KSSQSLLYSRNQKNYLA);
- a LCDR2 comprising amino acids having at least 80% identity with the amino acid sequence of SEQ ID NO:
- 5 (WASTRES);
- and
- a LCDR3 comprising amino acids having the amino acid sequence of SEQ ID NO:
- 6 (QQYYSYPLT).
An isolated antigen binding construct comprising amino acids having 100% identity with an amino acid sequence selected from the any one of the sequences listed in SEQ ID NOS:
- 23-44, 12-43, 12-45, 87-96, 110-115, 122-125, or 140-143.
Dependencies are inferred from the claim text.