Peanut allergy epitope
AssigneeVanderbilt University
InventorsBenjamin W. Spiller, Scott A. Smith
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Abstract
Disclosed herein is a composition comprising a mutant peanut (Arachis hypogaea) Ara h 6 polypeptide, a mutant Ara h 2 polypeptide, or a combination thereof in a pharmaceutically acceptable carrier, wherein the mutant Ara h 6 polypeptide and/or mutant Ara h 2 polypeptide has a reduced IgE response in a subject with a peanut allergy compared to wildtype Ara h 6 or Ara h 2 polypeptide. Also disclosed is a method for desensitizing or tolerizing a subject with a peanut allergy, comprising administering to the subject the mutant peanut Ara h 6 and/or Ara h 2 polypeptides disclosed herein. Also disclosed is a method for monitoring progress for the disclosed therapeutic methods.
Claims17
A composition comprising a mutant peanut (Arachis hypogaea) Ara h 6 polypeptide in a pharmaceutically acceptable carrier, wherein the mutant Ara h 6 polypeptide has a reduced IgE response in a subject with a peanut allergy compared to wildtype Ara h 6, and
- wherein the mutant Ara h 6 polypeptide has the amino acid sequence SEQ ID NO:1 with at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 substitutions at amino acid residues T68, Q69, M101, R110, A111, P112, Q113, R114, D104, D118, V119, S120, or a combination thereof.
(canceled)
The composition of claim 13, wherein the mutant Ara h 6 polypeptide has the amino acid sequence SEQ ID NO:14.
14-25. (canceled)
A composition comprising a mutant peanut (Arachis hypogaea) Ara h 2 polypeptide in a pharmaceutically acceptable carrier, wherein the mutant Ara h 2 polypeptide has a reduced IgE response in a subject with a peanut allergy compared to wildtype Ara h 2 polypeptide, and
- wherein the mutant Ara h 2 polypeptide has the amino acid sequence SEQ ID NO:2 with at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13 substitutions at amino acid residues N79, N80, Q81, R113, R122, A123, P124, Q125, R126, D128, D130, V131, E132, or a combination thereof.
Dependencies are inferred from the claim text.