Hiv-1 envelope glycopeptide nanoparticles and their uses

A recombinant fusion protein sequence comprising in order a V3 glycopeptide, a peptide linker and a self-assembling protein, wherein the fusion protein is comprised in a multimeric protein complex, wherein the fusion protein design is selected from the group consisting of:

• HV1301810, HV1301942, HV1301936, HV1301937, HV1301938, HV1301944, HV1301943, HV1301939, HV1301940, HV1301941, HV1302139, HV1302140, HV1302141, HV1302738 v2, HV1302739 v2, HV1302740 v2, HV1302741 v2, HV1302742 v2, HV1302743 v2, HV1302744 v2, HV1302745 v2, HV1302746 v2, HV1302747 v2, HV1302748 v2, HV1302749 v2, HV1302750 v2, HV1302751 V2, HV1302752 V2, HV1302753 V2, HV1302754 V2, HV1302755 V2, HV1302756 V2, HV1302757 V2, HV1302758 V2, HV1302759 V2, HV1302760 V2, and HV1302761 v2.