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US 2024/0390458 A1Published application
Treatment system for synergistically inhibiting a sprout angiogenesis
AssigneeCalifornia Northstate College of Pharmacy, LLC
InventorXiaodong Feng
Life of this patent
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Abstract
The teachings provided herein generally relate to a combination therapy and are directed to pharmaceutical compositions and methods for administering a combination of an αvβ3 antagonist with an α2β1 antagonist to a subject. The methods are for use in inhibiting, preventing, or reversing angiogenesis, as well as in treating cancer. In some embodiments, the compositions and methods include a combined administration of echistatin and VP12 (ECL12).
Claims20
A treatment system for synergistically inhibiting a sprout angiogenesis from vascular endothelial cells, the system comprising:
- a combination of
- about 0.1 μg/ml to about 10 μg/ml of SEQ ID NO:1;
- about 10 μg/ml VP12 of SEQ ID NO:2 and SEQ ID NO:3;
- wherein, the system synergistically inhibits the sprout angiogenesis of the vascular endothelial cells when contacting the combination with the sprouting vascular endothelial cells.
1 more element
Dependencies are inferred from the claim text.