Modified tripeptides for use in the treatment of a non-enveloped virus infection

A compound for use in the treatment of a non-enveloped virus infection in a subject, wherein said compound is a compound of Formula (I)

• AA-AA-AA-X—Y—Z (1)
• wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms;
• X is a N atom, which may be substituted by a branched or unbranched C1-C10 alkyl or aryl group which group may incorporate up to 2 heteroatoms selected from N, O and S;
• Y represents a group selected from —Ra—Rb—, —Ra—Rb—Rb— and —Rb—Rb—Ra— wherein
• Ra is C, O, S or N, and
• Rb is C;
• each of Ra and Rb may be substituted by C1-C4 alkyl groups or unsubstituted;
• and
• Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogen atoms, 2 or more of the cyclic groups may be fused and one or more of the cyclic groups may be substituted;
• the Z moiety incorporates a maximum of 15 non-hydrogen atoms;
• and
• wherein
• the bond between Y and Z is a covalent bond between Ra or Rb of Y and a non-hydrogen atom of one of the cyclic groups of Z.