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US 2024/0390409 A1Published application
Particle-mediated delivery of biologics
AssigneeMayo Foundation for Medical Education and Research
InventorsAtta Behfar, Andre Terzic
Life of this patent
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Abstract
A composition for delivering a biologic to a subject generally includes a particulate substrate and an mRNA encapsulated by the particulate substrate. In some cases, the mRNA bay be indirectly attached to the particulate substrate. The mRNA encodes at least one therapeutic polypeptide. The composition may be delivered to a tissue of a subject to provide a therapeutic benefit to the tissue.
Claims2
A method for improving cardiac function in a mammal, the method comprising:
- administering to the mammal a composition comprising a particle encapsulating an mRNA, the mRNA encoding a polypeptide useful for regenerating cardiac function and/or tissue to a mammal, thereby improving cardiac function of the mammal.
2-50. (canceled)
Dependencies are inferred from the claim text.