Combination of bcl-2/bcl-xl inhibitors and chemotherapeutic agent and use thereof

A method of treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a Bcl-2/Bcl-xL inhibitor and a therapeutically effective amount of a chemotherapeutic agent, wherein the Bcl-2/Bcl-xL inhibitor is

• or a pharmaceutically acceptable salt thereof,
• wherein the chemotherapeutic agent is selected from the group consisting of cisplatin, docetaxel, 5-fluorouracil, irinotecan;
• wherein the cancer is selected from the group consisting of breast cancer, small cell lung cancer, non-small cell lung cancer, prostate cancer, gastric cancer and colon cancer;
• with proviso that
• when the cancer is small cell lung cancer, the chemotherapeutic agent is cisplatin or irinotecan;
• when the cancer is non-small cell lung cancer, the chemotherapeutic agent is cisplatin, docetaxel;
• when the cancer is breast cancer, the chemotherapeutic agent is docetaxel;
• when the cancer is prostate cancer, the chemotherapeutic agent is docetaxel;
• when the cancer is gastric cancer, the chemotherapeutic agent is docetaxel, cisplatin, 5-fluorouracil;
• when the cancer is colon cancer, the chemotherapeutic agent is irinotecan.