Nicorandil derivatives
AssigneeUnicycive Therapeutics, Inc.
InventorsShalabh GUPTA, Sundeep DUGAR
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Abstract
Disclosed herein are pyridyl compounds. Also described are specific conjugated nicorandil compounds. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the pyridyl compounds are disclosed for the treatment of diseases or conditions related to kidney or kidney functions.
Claims18
A method for treating a disease or a condition selected from Chronic Kidney Disease, Transplant related Ischemia, Cisplatin induced Acute Kidney Injury (AKI), Aminoglycosides induced AKI, Tenofovir induced AKI, AKI after surgery for partial nephrectomy, AKI post kidney transplant, AKI in patients with Dialysis, AKI after Cardiac surgery, AKI in patients inside ICU, AKI caused by Cirrhosis or Sepsis, and AKI caused by hepatorenal syndrome in a mammal, where the method comprises administering to the mammal an effective disease-treating or condition-treating amount of a compound according to formula (Va) or formula (Vb):
- or a pharmaceutical composition thereof;
- wherein X− is a counter ion.
2-25. (canceled)
Dependencies are inferred from the claim text.