Compositions and methods for mitigating alcohol liver disease
AssigneesResearch Foundation of the City University of New York, Cornell University
InventorsSTEVEN TRASINO, LORRAINE GUDAS, XIAO-HAN TANG, MARTA MELIS
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Abstract
Specifically, the invention relates to compositions and methods for treating liver ailments, such as compositions and methods for attenuating or ameliorating the development of alcoholic liver disease (ALD), hepatic steatosis, liver oxidative stress and/or hepatic lipogenesis associated with alcohol consumption in a subject by administering a retinoic acid receptor-beta (RARβ) agonist.
Claims24
A method of treating, preventing, or ameliorating alcoholic liver disease (ALD) in a subject, comprising administering to said subject a therapeutically effective amount of a selective retinoic acid receptor-β2 (RARβ2) agonist or a pharmaceutically acceptable salt, ester, amide, prodrug thereof, or a combination thereof.
A method for inhibiting liver steatosis associated with alcohol consumption in a subject, comprising administering to said subject a therapeutically effective amount of a selective retinoic acid receptor-β2 (RARβ2) agonist or a pharmaceutically acceptable salt, ester, amide, prodrug thereof, or a combination thereof.
A method for inhibiting liver oxidative stress and/or hepatic lipogenesis associated with alcohol consumption in a subject, comprising administering to said subject a therapeutically effective amount of a selective retinoic acid receptor-β2 (RARβ2) agonist or a pharmaceutically acceptable salt, ester, amide, prodrug thereof, or a combination thereof.
Dependencies are inferred from the claim text.