Combinations of peripheral 5-ht2a receptor antagonists and central 5-ht2a receptor agonists

A method of treating a psychiatric disorder in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a combination of a peripheral serotonin receptor antagonist and a 5-HT2A receptor agonist, wherein the peripheral serotonin receptor antagonist and the 5-HT2A receptor agonist are present in one pharmaceutical composition comprising the peripheral serotonin receptor antagonist and the 5-HT2A receptor agonist and a pharmaceutically acceptable carrier therefor, or wherein the peripheral serotonin receptor antagonist and the 5-HT2A receptor agonist are present in two separate pharmaceutical compositions, wherein one pharmaceutical composition comprises the peripheral serotonin receptor antagonist and a pharmaceutically acceptable carrier therefor and the second pharmaceutical composition comprises the 5-HT2A receptor agonist and a pharmaceutically acceptable carrier therefor.