Derivatives of the protectin 10s,17s-dihda (pdx) and use thereof as antiviral, anti-inflammatory, and anti-diabetic agents
AssigneeUniversite Laval
InventorsRené MALTAIS, André MARETTE, Donald POIRIER, Jean-Yves SANCÉAU, Guy BOIVIN
Life of this patent
Estimating the term…
Abstract
Derivatives of 10S, 17S-diHIDA (protectin DX, PDX) and medicinal uses thereof are disclosed. These derivatives are specialized pro-resolving mediators (SPRMs). In specific embodiments, said derivatives are used in to prevent or treat viral infections (including influenza and coronavirus infections), insulin resistance, diabetes, and inflammatory disorders.
Claims33
A method of preventing, delaying the onset or reducing the severity of, preventing, or reversing the progression of, or treating a viral infection or disease in a subject, said method comprising administering a protectin, protectin analog, structural isomer, or a pharmaceutically acceptable salt thereof, to the subject.
11-31. (canceled)
A method of preventing, delaying the onset or reducing the severity of, preventing, or reversing the progression of, or treating insulin resistance or diabetes in a subject, said method comprising administering a protectin, protectin analog, structural isomer, or a pharmaceutically acceptable salt thereof, to the subject.
38-70. (canceled)
A method of preventing, delaying the onset or reducing the severity of, preventing or reversing the progression of, or treating an inflammatory disease, disorder, condition, or symptom in a subject, said method comprising administering a protectin, protectin analog, structural isomer, or a pharmaceutically acceptable salt thereof, to the subject.
74-80. (canceled)
83-84. (canceled)
A method of preventing, delaying the onset or reducing the severity of, preventing, or reversing the progression of, or treating an inflammatory disease, disorder, condition, or symptom that is secondary to another condition in a subject, said method comprising administering a protectin, protectin analog, structural isomer, or a pharmaceutically acceptable salt thereof, to the subject.
88-92. (canceled)
A method of preventing, delaying the onset or reducing the severity of, preventing, or reversing the progression of, or treating chronic low-level inflammation associated with chronic conditions in a subject, said method comprising administering a protectin, protectin analog, structural isomer, or a pharmaceutically acceptable salt thereof, to the subject.
Dependencies are inferred from the claim text.