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US 2024/0390264 A1Published application
Transdermal delivery formulations
AssigneeAlbert Einstein College of Medicine
InventorJoel M. Friedman
Life of this patent
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Abstract
A transdermal formulation for the delivery of one or more active agents to a subject is provided. The formulation can be applied to the treatment of various diseases or conditions associated with an elevated CD38 level.
Claims21
A transdermal formulation, comprising:
- (a) one or both of an effective amount of a curcuminoid and an effective amount of at least one flavonoid, wherein the curcuminoid is selected from the group consisting of curcumin, demethoxycurcumin, and bisdemethoxycurcumin;
- (b) a polyol in an amount sufficient to dissolve the effective amount of the curcuminoid and the at least one flavonoid;
- and optionally
- (c) fatty acid, wherein the polyol and the fatty acid are in a ratio ranging from about 10:1 to about 50:1 by weight,
- wherein the amounts of the polyol and the fatty acid are selected so that upon administration the effective amount of the NO booster is delivered transdermally.
2 more elements
The method of claim 19, wherein the CD38 is in a cell.
Dependencies are inferred from the claim text.