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US 2024/0390249 A1Published application
Materials and Methods for Inhibiting, Preventing, and Dispersing Biofilms
AssigneeUniversity of Wyoming
InventorsMark Gomelsky, Ahmed Elbakush, Alex M. Fulano
Life of this patent
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Abstract
Materials and methods are provided for preventing and dispersing biofilms. Methods and compositions are described for preventing and treating dental caries. Materials and methods are provided for producing antibiofilm agents from natural products, including maple (Acer sp.). Compositions are provided for inhibiting Sortase A activity in Bacillota.
Claims19
An oral care composition comprising:
- a carrier consisting essentially of an aqueous liquid;
- a first SrtA inhibiting agent provided in the aqueous liquid at a concentration in a range of 20 μM to 1000 μM, wherein the first SrtA inhibiting agent is selected from the group consisting of:
- nortrachelogenin-8′-O-β-D-glucopyranoside, lariciresinol, scopoletin, isoscopoletin, epicatechin gallate, epigallocatechin gallate, or abscisic acid;
- a second SrtA inhibiting agent provided in the aqueous liquid at a concentration in a range of 20 μM to 1000 μM, wherein the second SrtA inhibiting agent is selected from the group consisting of:
- nortrachelogenin-8′-O-β-D-glucopyranoside, lariciresinol, scopoletin, isoscopoletin, epicatechin gallate, epigallocatechin gallate, or abscisic acid;
- and wherein the second SrtA inhibiting agent is different from the first SrtA inhibiting agent;
- and
- a sweetener comprising at least one of xylitol, sorbitol, mannitol, or erythritol;
- wherein the composition contains less than 1.0 g/L sucrose;
- and
- wherein the composition is formulated as a liquid mouthwash, oral spray, or oral rinse.
8 more elements
An oral care composition comprising:
- an orally-acceptable vehicle;
- a sweetener;
- and
- an antibiofilm-effective amount of an active compound, wherein the active compound comprises at least two of:
- nortrachelogenin-8′-O-β-D-glucopyranoside, lariciresinol, scopoletin, isoscopoletin, epicatechin gallate, epigallocatechin gallate, or abscisic acid.
2 more elements
A cleaning composition for inhibiting biofilms, wherein the composition comprises:
- a vehicle, wherein the vehicle is aqueous;
- at least one of:
- a stabilizer, a buffer, an emulsifier, or a surfactant;
- and
- an antibiofilm-effective amount of at least one active compound, wherein the active compound is selected from:
- nortrachelogenin-8′-O-β-D-glucopyranoside, lariciresinol, scopoletin, isoscopoletin, epicatechin gallate, epigallocatechin gallate, or abscisic acid.
3 more elements
A method for making an antibiofilm composition comprising:
- preparing an aqueous wood biomass extract, wherein:
- the wood is maple, pecan, or hickory;
- and
- the extract comprises an antibiofilm-effective amount of an active compound, the active compound comprising at least one of:
- nortrachelogenin-8′-O-B-D-glucopyranoside, lariciresinol, scopoletin, isoscopoletin, epicatechin gallate, or abscisic acid;
- and
- combining the extract with at least one of:
- a buffer, a stabilizer, an emulsifier, or a surfactant.
5 more elements
Dependencies are inferred from the claim text.