Systems and methods for stereo-eeg implantation and resection surgeries

A method for determining recordable brain tissue for a patient, the method comprising:

• generating a head model for the patient;
• determining a plurality of voltages throughout the head model that result from a plurality of neural sources;
• determining a recording sensitivity throughout the head model based on whether the voltages are above a threshold value for the plurality of electrodes;
• and
• displaying a visualization of the recording sensitivity throughout the head model.

A method for determining implantation trajectories for a plurality of electrodes, the method comprising:

• generating a head model for the patient;
• determining a plurality of voltages throughout the head model that result from a plurality of neural sources;
• determining a recording sensitivity throughout the head model based on whether the voltages are above a threshold value for the plurality of electrodes;
• and
• determining implantation trajectories for the plurality of electrodes to maximize recording sensitivity for a brain region of interest.

A method for reconstructing propagating neural activity with time-dependent stereo-EEG data from a plurality of electrodes, the method comprising:

• simulating a static source reconstruction using the set of time-dependent stereo-EEG data;
• clustering adjacent populations of active neural sources together to generate time-dependent active clusters of neural sources;
• fitting a spatial trajectory to the time-dependent active clusters;
• constraining a search region to cortical points within a threshold distance of the spatial trajectory;
• simulating a propagating source reconstruction based on the search region and the spatial trajectory of the time-dependent active clusters;
• and
• displaying the propagating source in a three-dimensional head model.

A method for reconstructing dynamic stationary neural activity with time-dependent stereo-EEG data from a plurality of electrodes, the method comprising:

• parcellating of a cortical mesh into synchronously active spatially disparate sources;
• iteratively solving for a temporal basis function underlying the activity of spatially disparate sources, wherein a spatiotemporal link defines which temporal basis function maps to which source, and wherein hyperparameters define the number of temporal basis functions and which spatially disparate sources are active;
• wherein convergence occurs when the difference between subsequent reconstructed sources is below a threshold;
• and
• the spatial extents of each source are iteratively shrunk using a stationary source localization algorithm with the solved time courses for the spatially disparate sources.

A method comprising:

• generating a patient specific head model;
• determining implantation trajectories for a plurality of stereo-EEG electrodes that maximize a recording sensitivity for a region of interest;
• implanting the plurality of stereo-EEG electrodes in a patient head based on the implantation trajectories;
• recording time-dependent stereo-EEG data from the plurality of electrodes;
• reconstructing a dynamic source of neural activity based on the time-dependent stereo-EEG data;
• and
• displaying the source of neural activity in the patient specific head model.