Polymer-based microfluidic sample preparation chip
AssigneeThe Trustees of Columbia University in the City of New York
InventorsXiangsong FENG, Qiao Lin, Sandip Kaledhonkar, Ziao Fu, Joachim Frank
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Abstract
The present subject matter relates to devices and techniques for preparing a sample. The disclosed device can include a mixer, a reaction channel, and a micro sprayer. The mixer can be configured to mix at least two components and perform a splitting and recombination (SAR) mixing. The micro sprayer can be configured to generate a droplet of the sample. The mixer and the micro sprayer can be coupled through the reaction channel. The reaction channel can be a microcapillary tubing or a yin-yang reaction channel.
Claims40
A microfluidic device, comprising:
- a polymer-based mixer for mixing at least two components;
- wherein the mixer is selected from the group consisting of polydimethylsiloxane (PDMS), IP-S, IP-Q, and AZ photoresist;
- a reaction channel;
- and a polymer-based micro sprayer configured to generate a droplet,
- wherein the polymer-based mixer and the polymer-based micro sprayer are configured to be coupled through the reaction channel, wherein the polymer-based mixer is configured to perform a splitting and recombination (SAR) mixing, and wherein the reaction channel comprises a microcapillary tubing or a yin-yang channel.
A method for producing a sample, comprising mixing at least two components using a three-dimensional (3D) splitting and recombination (SAR) mixer;
- inducing a reaction between the at least two components in a reaction channel to generate the sample, wherein the reaction channel comprises either a microcapillary tubing or a yin-yang channel;
- and generating a droplet of the sample on a substrate using a micro sprayer.
A microfluidic device, comprising:
- a mixer comprising a polymer or glass for mixing at least two components;
- a reaction channel;
- and
- a micro sprayer comprising at least one of a polymer, glass, or silicon-based material, configured to generate a droplet,
- wherein the mixer and the micro sprayer are configured to be coupled through the reaction channel, wherein the mixer is configured to perform a splitting and recombination (SAR) mixing, and wherein the reaction channel comprises a microcapillary tubing or a yin-yang channel.
A microfluidic device for producing a sample, comprising:
- a three-dimensional (3D) splitting and recombination (SAR) mixer configured to mix at least two components, wherein the mixer comprises components made in a material selected from the group consisting of a polymer, glass, and silicon-based materials;
- a reaction channel coupled to the mixer, wherein the reaction channel comprises either a microcapillary tubing or a yin-yang channel, and is configured to induce a reaction between the at least two components to generate the sample;
- and
- a micro sprayer coupled to the reaction channel and configured to generate a droplet of the sample on a substrate, wherein the micro sprayer comprises components made in a material selected from the group consisting of a polymer, glass, and silicon-based materials.
Dependencies are inferred from the claim text.