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US 2024/0382956 A1Published application
Flow cell device and use thereof
AssigneeElement Biosciences, Inc.
InventorsMinghao GUO, Leon Zilun ZHANG, Chunhong ZHOU, Matthew KELLINGER, Michael PREVITE
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Abstract
Flow cell devices, cartridges, and systems are described that provide reduced manufacturing complexity, lowered consumable costs, and flexible system throughput for nucleic acid sequencing and other chemical or biological analysis applications. The flow cell device can include a capillary flow cell device or a microfluidic flow cell device.
Claims21
1-26. (canceled)
A system for identifying a nucleic acid sequence, the system comprising:
- (a) a flow cell comprising a microfluidic chip, wherein the microfluidic chip comprises at least two microfluidic channels, wherein a surface of a microfluidic channel of the at least two microfluidic channels is configured to immobilize a nucleic acid molecule comprising the nucleic acid sequence;
- (b) a reservoir in fluid communication with the at least two microfluid channels, wherein the reservoir comprises a fluorescent detection reagent contained therein, wherein the fluorescent detection reagent is for a nucleic acid sequencing reaction;
- (c) a fluorescence imaging module configured to acquire a fluorescent image of the surface of the microfluidic channel to obtain two or more fluorescent signals from the nucleic acid molecule labeled with the fluorescent detection agent;
- and
- (d) a computer system comprising a programmable logic circuit programmed to process in parallel sequencing data generated from the two or more fluorescent signals in (c) to determine the nucleic acid sequence.
2 more elements
Dependencies are inferred from the claim text.