Systems and methods of rapid and autonomous detection of aerosol particles
AssigneeZeteo Tech, Inc.
InventorsMichael MCLOUGHLIN, Nathaniel K. JONES, Daniel Jeffrey GUSSIN
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Abstract
Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.
Claims34
A sample capture and analysis system for analyzing aerosol analyte particles, the system including:
- a fresh sample disk station configured to receive a fresh disk cartridge having one or more fresh sample disks;
- a spent sample disk unloader station;
- an aerosol sample collection station;
- a sample disk holder including a stub, the sample disk holder configured to move in at least two directions (X-Y-Z) orthogonal to each other using one or more of a stepper motor or actuator using a predetermined analysis sequence to engage with each station;
- and
- an analysis station including a time-of-flight mass spectrometer (TOFMS).
A sample capture and analysis system for analyzing aerosol analyte particles, the system including:
- a fresh sample disk station configured to receive a fresh disk cartridge having one or more fresh sample disks;
- a spent sample disk unloader station;
- an aerosol sample collection station;
- a rotatable sample disk holder including a stub, the sample disk holder configured to move in at least two directions (⊖-Z) using one or more of a stepper motor or rotary actuator using a predetermined analysis sequence to engage with each station;
- and
- one or more analysis stations.
A sample capture and analysis system for analyzing aerosol analyte particles, the system including:
- a fresh sample disk station configured to receive a fresh disk cartridge having one or more fresh sample disks;
- a spent sample disk unloader station;
- an aerosol sample collection station;
- at least two rotatable sample disk holders, each including a stub, wherein each sample disk holder:
- includes one or more of a stepper motor or rotary actuator and is configured to move in at least two directions (⊖-Z);
- and
- configured to engage with one or more stations according to a predetermined analysis sequence;
- and
- one or more analysis stations.
Dependencies are inferred from the claim text.