Determining Properties of Samples Using Quantum Sensing

The method according to any one of the preceding claims, wherein the detected photoluminescence intensity is measured during an excitation phase of the illumination signal applied to the quantum sensor.

The method according to any one of the preceding claims, comprising the step of detecting the photoluminescence intensity at one or more wavelengths in a range of about 620 nm to about 850 nm, preferably between about 637 nm to about 800 nm.

The method according to any one of the preceding claims, comprising the step of measuring rate of decay of the detected photoluminescence intensity, wherein the rate of decay (1/T1) indicates a property of the sample corresponding to loading factor of the molecular metal ligand.

The method according to any one of the preceding claims, comprising the step of comparing the measured rate of decay of the detected photoluminescence intensity with a background rate of decay measured from the quantum sensor when the illumination signal is applied in the absence of the sample.

The method according to any one of the preceding claims, wherein the molecular metal-ligand is selected from a group comprising metalloproteins, metal-chelating agents and other metal-binding agents.

The method according to any one of the preceding claims, wherein the quantum sensor comprises an addressable spin defect in a semiconductor material.

The method according to any one of the preceding claims, wherein the quantum sensor comprises a plurality of quantum sensor elements and wherein exposing the quantum sensor elements to the sample comprises providing the quantum sensor elements in suspension within a fluid comprising the sample.

The method according to any one of the preceding claims, wherein the sample is a biological sample, preferably a biological fluid sample.

The method according to any one of the preceding claims, wherein the photoluminescence intensity is detected using a CCD (charge-coupled device) or a complementary metal oxide semiconductor (sCMOS) and optionally, wherein the detected photoluminescence intensity conveys uniformity of the biological sample with respect to the quantum sensor.

Use of the method according to any one of the preceding claims in an apparatus, system or protocol for diagnosing one or more of iron deficiency, iron deficiency anaemia, iron overload and inflammation.

Use of the method according to any one of the preceding claims in a method, system or apparatus guiding management and/or treatment of one or more of iron deficiency, iron deficiency anaemia, haemochromatosis, iron overload and clinically diagnosed inflammation.